故事讲述了女主角从一个家族中不受重视的庶女，因一次意外获得神秘力量，开启逆袭之路，最终成为令人敬畏的“毒妃”。剧中，她凭借智慧和医术，化解危机，并在复杂的宫廷斗争中逐步成长
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9.0全65集医神 林之行获世界医术大赛三冠王后失踪，一年后化名实习生藏于济世堂，常遭师兄师妹刁难。首富陈楠病危求医，济世堂仅留林之行等人，师兄方悟抓药出错致陈楠吐血。林之行配药施救，遭杜瑞坤质疑，萧逸尘试药证其效。双方展开生死战，首轮剥蛋壳比试点，林之行战胜倭国 “鬼医” 后离开。后他助萧逸尘之女，查清师尊被害真相，凶手终受惩处。
9.0全31集林静含辛茹苦养家，竟发现丈夫赵城隐瞒富豪身份，与前女友挥霍。赵城漠视妻女，致林静流产、女儿遇险，生日会更是伤透女儿心。林静带女离开，其林氏千金身份曝光，开启新生。赵城追悔，虽救女却难挽回……
9.0全44集王守根含冤入狱三年，出狱后遭全村唾骂，父母偏信儿媳妇李金花，认为王守根家暴妻子、害女儿烫伤。李金花表面贤惠柔弱，屡屡春秋笔法诱导众人认为王守根十恶不赦，二人对峙时王守根一次次揭露过去的真相却被李金花以各种片面的事实倒打一耙
10.0全61集田珍因债务问题被迫卷入非法交易，在目睹同伴为自保而背叛他人后，她暗中留下关键证据，这成为她后来转变的起点。随着剧情发展，田珍经历了诸多磨难，如在废弃工厂被困三日三夜，凭借野外生存技巧顽强求生，这段经历让她意识到真正的牢笼是自我设限的心理枷笼。她逐渐从被动承受者转变为主动破局者，面对黑帮头目的威胁，她凭借智慧和勇气将其送入法网，完成了从受害者到猎人的身份转换。在情感方面，她也经历了与昔日好友的艰难对峙，最终选择以宽容和责任感来处理。
全83集王小柯刚出生，被京都王家掉包换走，在外流浪五年，好在遇到师父，学得修仙法。五岁那年，被七姐王思琪找到回到家。一边与八个姐姐过着幸福的日子，一边展露实力， 震惊八位姐姐，这个五岁的小娃娃藏着多少马甲。
10.0全76集叶归华嫁给了她喜欢的顾青山，但顾青山与她结婚是为了照顾青梅竹马而不被说闲话，他一直爱的是自己的青梅。叶归华得知真相后毅然离开，顾青山这才意识到自己已经喜欢上叶归华，但为时已晚
8.0全109集现代穿越女陈曦，一睁眼就遇债主逼债、要卖她抵债！绝境中，她靠现代知识将廉价山楂做成冰糖葫芦，拉红果村村民搞生产，日赚数两银子。面对诬陷、贪官打压，她借力翻盘，还解锁新技能。更意外与微服的太子杨逍结缘，获皇帝赏识封子爵、赐领地。她拒当太子妃，一心搞农业、建商号，却被皇帝设赌约，三年让陈国粮产增三成，否则就得回府做王妃！看种田大佬如何搞事业、应对甜蜜“威胁”！
全66集大夏嫡公主李嫣然为了帮助弟弟登基远嫁和亲，数年后归国却反遭百官指责与苏氏刺杀，她不在隐忍决定诛杀苏氏，同时弟弟献上梁国皇子叶云枫为面首，没想到竟是李嫣然昔日救命恩人。这时她也察觉到弟弟和皇后在背后下毒，她立誓要登顶权力之巅，令负她者尽悔。
全35集影后顾青漫为爱退圈五年，虔诚遵守佛子沈玉辰的“三戒”：退隐娱乐圈、盘佛珠静心、抄千遍心经，只为换他真心。然而周静的出现撕破谎言——沈玉辰逼顾青漫退圈实为给前任铺路，更屡屡为周静破戒（饮酒食荤、亲密同寝）。